Pain sensitivity and analgesic use among 10,486 adults: the Tromsø study. Samuelsen PJ, Nielsen CS, Wilsgaard T, Stubhaug A, Svendsen K, Eggen AE. BMC Pharmacol Toxicol. 2017 Jun 9;18(1):45. doi: 10.1186/s40360-017-0149-2. https://www.ncbi.nlm....

Opioid receptor modulation of neural circuits in depression: What can be learned from preclinical data? Puryear CB, Brooks J, Tan L, Smith K, Li Y, Cunningham J, Todtenkopf MS, Dean RL, Sanchez C. Neurosci Biobehav Rev. 2019 Dec 9;108:658-678. d...

Opium use and mortality in Golestan Cohort Study: prospective cohort study of 50,000 adults in Iran. Khademi H, Malekzadeh R, Pourshams A, Jafari E, Salahi R, Semnani S, Abaie B, Islami F, Nasseri-Moghaddam S, Etemadi A, Byrnes G, Abnet CC, Dawse...

Evaluation of dynorphin and kappa-opioid receptor level in the human blood lymphocytes and plasma: Possible role as a biomarker in severe opioid use disorder. Shahkarami K, Vousooghi N, Golab F, Mohsenzadeh A, Baharvand P, Sadat-Shirazi MS, Babha...

Tramadol. 'Safer opioid' has sparked a crisis in vulnerable countries Reports rolled in with escalating urgency—pills seized by the truckload, pills swallowed by schoolchildren, pills in the pockets of dead terrorists.  These pills, th...

American College of Emergency Physicians: Opioid Resources  Every day emergency physicians see the devastating consequences of the opioid epidemic. ACEP is one of the leaders in the battle against this epidemic. Here are some of the initiat...