| Hans-Günter Meyer-Thompson | Opioide
NIDA: Promising Advances in the Search for Safer Opioids
Two novel compounds powerfully suppressed animals’ pain responses, while producing little or none of the respiratory depression and liability for misuse and abuse associated with morphine and other typical opioids.
One of the compounds was extensively tested in a monkey model, laying key groundwork for moving to human trials.
The other compound was identified using computational modeling based on x-ray crystallography of a receptor’s structure, and exemplifies that technique’s potential for identifying novel compounds that can meet highly specific therapeutic needs. (NIDA Notes, 23.02.2017)
https://www.drugabuse.gov/news-events/nida-notes/2017/02/promising-advances-in-search-safer-opioids