| Hans-Günter Meyer-Thompson | Kokain
Why Females Are More Sensitive to Cocaine
Why Females Are More Sensitive to Cocaine
This research:
Examined why females are more sensitive than males to the rewarding and motivational effects of stimulant drugs.
Demonstrated that the female hormone estradiol is responsible for the increased sensitivity.
Identified two signaling pathways—mGluR5 and the cannabinoid CB1R pathways—through which estradiol mediates enhanced escalation of drug administration and greater euphoria in females. (NIDA Notes, 03.08.2017)
https://www.drugabuse.gov/news-events/nida-notes/2017/08/why-females-are-more-sensitive-to-cocaine