| Hans-Günter Meyer-Thompson | Torsade-de-Pointes-Tachykardie
The opioid methadone induces a local anaesthetic-like inhibition of the cardiac Na⁺ channel, Na(v)1.5.
The opioid methadone induces a local anaesthetic-like inhibition of the cardiac Na⁺ channel, Na(v)1.5.
Schulze V, Stoetzer C, O'Reilly AO, Eberhardt E, Foadi N, Ahrens J, Wegner F, Lampert A, de la Roche J, Leffler A.
Br J Pharmacol. 2014 Jan;171(2):427-37. doi: 10.1111/bph.12465.