A putative binding model of nitazene derivatives at the μ-opioid receptor.  Clayton J, Shi L, Robertson MJ, Skiniotis G, Michaelides M, Stavitskaya L, Shen J.  Neuropharmacology. 2025 Aug 1;273:110437. doi: 10.1016/j.neuropharm.2025.1104…

Drugs repurposed against morphine and heroin dependence: molecular docking, DFT, MM-GBSA-based MD simulation studies.  Malik, J.A., Wani, M.A., Dar, M.O. et al. In Silico Pharmacol. 13, 67 (2025). https://doi.org/10.1007/s40203-025-…

Dipyanone, a new methadone-like synthetic opioid: In vitro and in vivo human metabolism and pharmacological profiling.  Berardinelli D, Kutzler J, Taoussi O, Zaami S, Pichini S, Basile G, Busardò FP, Auwärter V, Carlier J.  Arch Toxicol…

A new synthetic opioid threat: A comprehensive review on MT-45.  Kadem SN, Arslan Z, Turkmen Z. Forensic Sci Int. 2025 Apr 22;371:112479. doi: 10.1016/j.forsciint.2025.112479. Epub ahead of print. PMID: 40273834. Abstract https://www.science…

Guinea. ‘Kush destroys them’: the Guinean rehab clinic tackling a drug epidemic Experts say a crisis is under way in Guinea, fuelled by a growing market run by cross-border trafficking syndicates. (Guardian, UK, 20.04.2025) https://www.theguardian…

Tapentadol as a drug of abuse - A preliminary report.  Shivaprakash P, Shukla L, Joshi S, Mahadevan J, Kandasamy A, Chand PK, Benegal V, Murthy P.  Indian J Psychiatry. 2025 Feb;67(2):256-259. doi: 10.4103/indianjpsychiatry.indianjpsychi…